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18-MethoxycoronaridineSynthetic iboga alkaloid congenerThe following is a list of selected publications. Abstract links in bold* indicate full-text articles.
1. Metabolism of 18-Methoxycoronaridine, an Ibogaine Analog, to 18-Hydroxycoronaridine by Genetically Variable CYP2C19. Zhang W, Ramamoorthy Y, Tyndale RF, Glick SD, Maisonneuve IM, Kuehne ME, Sellers EM. Drug Metab Dispos 2002 Jun 1;30(6):663-669 Abstract 2. Antagonism of alpha3beta4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Glick SD, Maisonneuve IM, Kitchen BA, Fleck MW. Eur J Pharmacol 2002 Mar 1;438(1-2):99-105 Abstract 3. Drug discrimination studies with ibogaine. Helsley S, Rabin RA, Winter JC. Alkaloids Chem Biol 2001;56:63-77 Abstract 4. 18-MC reduces methamphetamine and nicotine self-administration in rats. Glick SD, Maisonneuve IM, Dickinson HA. Neuroreport 2000 Jun 26;11(9):2013-5 Abstract 5. Pharmacological comparison of the effect of ibogaine and 18-methoxycoronaridine on isolated smooth muscle from the rat and guinea-pig. Mundey MK, Blaylock NA, Mason R, Glick SD, Maisonneuve IM, Wilson VG. Br J Pharmacol 2000 Apr;129(8):1561-8 Abstract 6. Synthesis of enantiomerically pure (+)- and (-)-18-methoxycoronaridine hydrochloride and their preliminary assessment as anti-addictive agents. King CH, Meckler H, Herr RJ, Trova MP, Glick SD, Maisonneuve IM. Bioorg Med Chem Lett 2000 Mar 6;10(5):473-6 Abstract 7. 18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action. Glick SD, Maisonneuve IM, Szumlinski KK. Ann N Y Acad Sci 2000;914:369-86 Abstract* 8. Development of novel medications for drug addiction. The legacy of an African shrub. Glick SD, Maisonneuve IM. Ann N Y Acad Sci 2000;909:88-103 Abstract* 9. Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats. Wei D, Maisonneuve IM, Kuehne ME, Glick SD. Brain Res 1998 Aug 3;800(2):260-8 Abstract 10. Effects of 18-methoxycoronaridine on acute signs of morphine withdrawal in rats. Rho B, Glick SD. Neuroreport 1998 May 11;9(7):1283-5 Abstract 11. Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats. Rezvani AH, Overstreet DH, Yang Y, Maisonneuve IM, Bandarage UK, Kuehne ME, Glick SD. Pharmacol Biochem Behav 1997 Oct;58(2):615-619. Abstract 12. Time-dependent interactions between iboga agents and cocaine. Maisonneuve IM, Visker KE, Mann GL, Bandarage UK, Kuehne ME, Glick SD. Eur J Pharmacol 1997 Oct 8;336(2-3):123-126. Abstract 13. 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Glick SD, Kuehne ME, Maisonneuve IM, Bandarage UK, Molinari HH. Brain Res 1996 May 6;719(1-2):29-35. Abstract Check Medline here to find out about the most recent publications.
![]() 18-methoxycoronaridine molecule
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