Ibogaine research update: phase I human study. Sanchez-Ramos, J. and Mash, D.C. Multidisciplinary Association for Psychedelic Studies 4:11, 1994.
Abstract: We have recently received approval to begin Phase I
studies to assess the safety, metabolism and pharmacokinetics
of ibogaine in volunteers who have already experienced ibogaine.
As of the moment, the effects of 1 mg/kg p.o. have been studied
in three volunteers who had previously experienced ibogaine at
much higher doses while in Holland. No tremor or ataxia was noted,
and no hallucinogenic effects were noted. The subjects felt nothing
at all other than perhaps being somewhat calmer than usual. Pharmacokinetic
profiling is currently being done with samples of blood taken
from these subjects. These results are to be reported to the FDA
before commencing with the next dosage level, 2 mg/kg.
The Ibogaine Dossier